%0 Journal Article
%T Brugada syndrome: a review and the role of epicardial ablation in management.
%A Abuzuagaia OJ
%A Abozguia K
%A Darrat Y
%J Egypt Heart J
%V 76
%N 1
%D 2024 May 7
%M 38713300
暂无%R 10.1186/s43044-024-00485-3
%X <B>BACKGROUND: </B>Brugada syndrome (BrS) is an inherited arrhythmogenic syndrome characterized by cove-shaped ST-segment elevation in leads V1-V3 and incomplete or complete right bundle branch block. BrS exhibits autosomal dominant inheritance with incomplete penetrance and a male predominance. It carries a significant risk of sudden cardiac death due to ventricular fibrillation (VF).<BR><B>METHODS: </B>Recent studies have highlighted the presence of epicardial fibrosis as a proarrhythmic substrate in BrS, revolutionizing our understanding of the disease's pathophysiology. Catheter ablation has emerged as a crucial intervention for symptomatic BrS patients experiencing recurrent episodes of ventricular tachycardia (VT) or VF. By potentially obviating the need for implantable cardioverter-defibrillator (ICD) implantation, epicardial ablation offers a promising therapeutic approach.<BR><B>CONCLUSIONS: </B>This review emphasizes the significance of current evidence and ongoing research in shaping the role of epicardial ablation as a curative strategy in BrS management, highlighting its potential benefits and the necessity for further investigation.