%0 Journal Article
%T Novel Effective Medical Therapy for Acanthamoeba Keratitis.
%A Di Zazzo A
%A De Gregorio C
%A Coassin M
%J Eye Contact Lens
%V 50
%N 6
%D 2024 Jun 1
%M 38709240
%F 3.152
%R 10.1097/ICL.0000000000001092
%X <B>OBJECTIVE: </B>To report first clinical use of novel medical treatment for Acanthamoeba keratitis.<BR><B>METHODS: </B>Interventional observational case series. Two patients with Acanthamoeba keratitis were unsuccessfully treated with polihexanide (PHMB) 0.02% and propamidine 0.1% for 6 weeks, then all were shifted in a compassionate use of PHMB 0.08% with novel standardized protocol. The postinterventional follow-up of patients was at least 7 months.<BR><B>RESULTS: </B>PHMB 0.08% eyedrops in a novel standardized protocol improved infection resolution and led to complete healing of the lesion after 4 weeks in the two cases. Corneal opacities and neovascularization decreased slowly, best-corrected visual acuity slightly improved and progressively increased in the further 7 months, and no infection recurrence occurred.<BR><B>CONCLUSIONS: </B>This preliminary report of two cases shows promising response to polihexanide 0.08% lowering drastically the illness duration, with reduced chance of recurrence, and mostly improving patients' quality of life.