%0 Journal Article
%T Chromosomal abnormalities study for anembryonic pregnancy by BACs-on-Beads technique.
%A Onsod P
%A Jaranasaksakul W
%A Chareonsirisuthigul T
%A Parinayok R
%A Rerkamnuaychoke B
%A Areesirisuk P
%J Eur J Obstet Gynecol Reprod Biol
%V 298
%N 0
%D 2024 Jul 30
%M 38705011
%F 2.831
%R 10.1016/j.ejogrb.2024.04.041
%X <B>OBJECTIVE: </B>This study evaluated the BACs-on-Beads™ (BoBs) efficiency assay in detecting chromosomal anomalies in products of conception (POC) specimens associated with anembryonic pregnancy (AP) among Thai pregnant women.<BR><B>METHODS: </B>Retrospective analysis applied the BoBs™ assay to examine AP samples from 2010 to 2022. The incidences of AP with chromosomal abnormalities were reported.<BR><B>RESULTS: </B>Assessment of villi from anembryonic pregnancy samples found normal chromosome complement in 50% of the cases, while the remainder showed chromosomal abnormalities. Trisomy 16 was found in 15% of the cases and trisomies 22, 15, and 19 in 9.6%, 3.8%, and 3.8%, respectively. Advanced maternal age was associated with a higher incidence of aneuploidy.<BR><B>CONCLUSIONS: </B>The BoBs™ assay effectively detected diverse chromosomal abnormalities in villi samples from POC. The diagnostic utility of the BoBs™ assay was highlighted in identifying chromosomal irregularities in AP cases. Trisomy 16 possessed the most chromosomal abnormalities in the AP samples.