%0 Journal Article
%T Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis.
%A Chen Q
%A Li J
%J Future Microbiol
%V 19
%N 10
%D 2024 Jul 2
%M 38700285
%F 3.553
%R 10.2217/fmb-2023-0237
%X Aim: This study aims to explore the molecular mechanisms of cystic fibrosis (CF) complicated with nontuberculous mycobacteria (NTM) infection. Materials & methods: Expression profiles of CF with NTM-infected patients were downloaded from GEO database. Intersection analysis yielded 78 genes associated with CF with NTM infection. The protein-protein interaction (PPI) network and the functions of hub genes were investigated. Results: Five hub genes (PIK3R1, IL1A, CXCR4, ACTN1, PFN1) were identified, which were primarily enriched in actin-related biological processes and pathways. Transcription factors RELA, JUN, NFKB1 and FOS that regulated hub genes modulated IL1A expression, while 21 other transcription factors regulated CXCR4 expression. Conclusion: In summary, this study may provide new insights into the mechanisms of CF with NTM infection.<BR>[Box: see text].