%0 Journal Article
%T Predictability of B cell clonal persistence and immunosurveillance in breast cancer.
%A Sammut SJ
%A Galson JD
%A Minter R
%A Sun B
%A Chin SF
%A De Mattos-Arruda L
%A Finch DK
%A Schätzle S
%A Dias J
%A Rueda OM
%A Seoane J
%A Osbourn J
%A Caldas C
%A Bashford-Rogers RJM
%J Nat Immunol
%V 25
%N 5
%D 2024 May
%M 38698238
%F 31.25
%R 10.1038/s41590-024-01821-0
%X B cells and T cells are important components of the adaptive immune system and mediate anticancer immunity. The T cell landscape in cancer is well characterized, but the contribution of B cells to anticancer immunosurveillance is less well explored. Here we show an integrative analysis of the B cell and T cell receptor repertoire from individuals with metastatic breast cancer and individuals with early breast cancer during neoadjuvant therapy. Using immune receptor, RNA and whole-exome sequencing, we show that both B cell and T cell responses seem to coevolve with the metastatic cancer genomes and mirror tumor mutational and neoantigen architecture. B cell clones associated with metastatic immunosurveillance and temporal persistence were more expanded and distinct from site-specific clones. B cell clonal immunosurveillance and temporal persistence are predictable from the clonal structure, with higher-centrality B cell antigen receptors more likely to be detected across multiple metastases or across time. This predictability was generalizable across other immune-mediated disorders. This work lays a foundation for prioritizing antibody sequences for therapeutic targeting in cancer.