%0 Journal Article
%T Concomitant human papillomavirus (HPV) vaccination and screening for elimination of HPV and cervical cancer.
%A Arroyo Mühr LS
%A Gini A
%A Yilmaz E
%A Hassan SS
%A Lagheden C
%A Hultin E
%A Garcia Serrano A
%A Ure AE
%A Andersson H
%A Merino R
%A Elfström KM
%A Baussano I
%A Dillner J
%J Nat Commun
%V 15
%N 1
%D 2024 May 1
%M 38693149
%F 17.694
%R 10.1038/s41467-024-47909-x
%X HPV vaccination with concomitant HPV-based screening of young women has been proposed for faster cervical cancer elimination. We describe the baseline results of a population-based trial of this strategy to reduce the incidence of HPV. All 89,547 women born 1994-1999 and resident in the capital region of Sweden were personally invited to concomitant HPV vaccination and HPV screening with 26,125 women (29.2%) enrolled between 2021-05-03 and 2022-12-31. Baseline HPV genotyping of cervical samples from the study participants finds, compared to pre-vaccination prevalences, a strong decline of HPV16 and 18 in birth cohorts previously offered vaccination, some decline for cross-protected HPV types but no decline for HPV types not targeted by vaccines. Our dynamic transmission modelling predicts that the trial could reduce the incidence of high-risk HPV infections among the 1994-1998 cohorts by 62-64% in 3 years. Baseline results are prevalences of HPV infection, validated transmission model projections, and power estimates for evaluating HPV incidence reductions at follow-up (+/-0.1% with 99.9% confidence). In conclusion, concomitant HPV vaccination and HPV screening appears to be a realistic option for faster cervical cancer elimination. Clinicaltrials.gov identifier: NCT04910802; EudraCT number: 2020-001169-34.