%0 Journal Article
%T Regulation of VEGF-A expression and VEGF-A-targeted therapy in malignant tumors.
%A Kang Y
%A Li H
%A Liu Y
%A Li Z
%J J Cancer Res Clin Oncol
%V 150
%N 5
%D 2024 Apr 30
%M 38687357
%F 4.322
%R 10.1007/s00432-024-05714-5
%X Vascular endothelial growth factor A (VEGF-A), a highly conserved dimeric glycoprotein, is a key regulatory gene and a marker molecule of angiogenesis. The upregulation of VEGF-A facilitates the process of tumor vascularization, thereby fostering the initiation and progression of malignant neoplasms. Many genes can adjust the angiogenesis of tumors by changing the expression of VEGF-A. In addition, VEGF-A also exhibits immune regulatory properties, which directly or indirectly suppresses the antitumor activity of immune cells. The emergence of VEGF-A-targeted therapy alone or in rational combinations has revolutionized the treatment of various cancers. This review discusses how diverse mechanisms in various tumors regulate VEGF-A expression to promote tumor angiogenesis and the role of VEGF-A in tumor immune microenvironment. The application of drugs targeting VEGF-A in tumor therapy is also summarized including antibody molecule drugs and traditional Chinese medicine.