%0 Journal Article
%T Sucrose-Powered Liposome Nanosensors for Urinary Glucometer-Based Monitoring of Cancer.
%A Zhou D
%A Zhang Z
%A Pan L
%A Wang Y
%A Yang J
%A Gao Y
%A Song Y
%J Angew Chem Int Ed Engl
%V 63
%N 28
%D 2024 07 8
%M 38687277
%F 16.823
%R 10.1002/anie.202404493
%X Timely detection of early-stage cancer holds immense potential in enhancing prognostic outcomes. There is an increasing desire for versatile tools to enable simple, sensitive, and cost-effective cancer detection. By exploiting the extraintestinal metabolic inertness and efficiency renal clearance of sucrose, we designed a liposome nanosensor using sucrose as a messenger to convert tumor-specific esterase activity into glucose meter readout, enabling economical and sensitive urinalysis for cancer detection in point-of-care testing (POCT). Our results demonstrate that the nanosensors exhibited significant signal differences between tumor-bearing and healthy mice in both orthotopic and metastatic tumor models. Additionally, efficient elimination of the nanosensors through the hepatobiliary pathway was observed with no significant toxicity. Such a non-invasive diagnostic modality significantly assists in personalized pharmacological treatment and follow-up efficacy assessment. We envision that this modular liposome nanosensor platform might be applied for economically detecting diverse diseases via a simple urinary test.