%0 Journal Article
%T Technological advancements in functional interpretation of genome-wide association studies (GWAS) findings: bridging the gap to clinical translation.
%A Aherrahrou R
%A Kaikkonen MU
%J FEBS Lett
%V 0
%N 0
%D 2024 Apr 29
%M 38683017
%F 3.864
%R 10.1002/1873-3468.14884
%X Genome-wide association studies (GWAS) significantly advanced our understanding of the genetic underpinnings of diseases. However, challenges persist, particularly in interpreting non-coding variants in linkage disequilibrium that affect genes in disease-relevant cells. Addressing key obstacles-identifying causal variants, uncovering target genes, and understanding their network impact-is crucial. This graphical review navigates advanced techniques to fully leverage GWAS for future therapeutic breakthroughs.