%0 Case Reports
%T Juvenile xanthogranuloma manifesting with LCH-associated neurodegenerative disease-like radiological findings.
%A Daifu T
%A Umeda K
%A Yokoyama A
%A Yoshida T
%A Saida S
%A Kato I
%A Hiramatsu H
%A Kudo K
%A Higuchi Y
%A Takita J
%J Pediatr Blood Cancer
%V 71
%N 7
%D 2024 Jul 28
%M 38679849
%F 3.838
%R 10.1002/pbc.31043
%X Here, we describe two patients with juvenile xanthogranuloma (JXG) manifesting with Langerhans cell histiocytosis (LCH)-associated neurodegenerative disease (ND)-like radiological findings. One patient showed typical radiological abnormalities at onset, which worsened with progressing central nervous system symptoms 7 years after LCH-oriented chemotherapy. Another showed spontaneous regression of clinical symptoms, with a transient radiological change 1 year after salvage chemotherapy for recurrence of JXG. These data regarding JXG-associated ND will facilitate future investigation of the disease, as well as development of therapeutic interventions.