%0 Journal Article
%T Invasive fungal disease in children with solid tumors: An Australian multicenter 10-year review.
%A Jain N
%A Ryan AL
%A Haeusler GM
%A McMullan BJ
%A Moore AS
%A Bartlett AW
%A Blyth CC
%A Kotecha RS
%A Yeoh DK
%A Clark JE
%J Pediatr Blood Cancer
%V 71
%N 7
%D 2024 Jul 28
%M 38679843
%F 3.838
%R 10.1002/pbc.31031
%X Invasive fungal disease (IFD) occurs less frequently during treatment for solid compared to hematological malignancies in children, and risk groups are poorly defined. Retrospective national multicenter cohort data (2004-2013) were analyzed to document prevalence, clinical characteristics, and microbiology of IFD. Amongst 2067 children treated for solid malignancy, IFD prevalence was 1.9% overall and 1.4% for proven/probable IFD. Of all IFD episodes, 42.5% occurred in patients with neuroblastoma (prevalence 7.0%). Candida species comprised 54.8% of implicated pathogens in proven/probable IFD. In children with solid tumors, IFD is rare, and predominantly caused by yeasts.Routine prophylaxis may not be warranted.