%0 Journal Article
%T Advancing Postoperative Pain Management in Oral Cancer Patients: A Systematic Review.
%A Inchingolo AM
%A Dipalma G
%A Inchingolo AD
%A Palumbo I
%A Guglielmo M
%A Morolla R
%A Mancini A
%A Inchingolo F
%J Pharmaceuticals (Basel)
%V 17
%N 4
%D 2024 Apr 22
%M 38675500
%F 5.215
%R 10.3390/ph17040542
%X The goal of this review is to shed light on the management of orofacial discomfort after a cancer diagnosis in the head and neck region. A search was conducted on PubMed, Scopus, and Web of Science to identify studies on postoperative pain control in oral cancer. The review included open-access research, investigations into pain management, randomized clinical trials, retrospective studies, case-control studies, prospective studies, English-written studies, and full-text publications. Exclusion criteria included animal studies; in vitro studies; off-topic studies; reviews, case reports, letters, or comments; and non-English language. Three reviewers independently accessed databases and assigned a quality rating to the chosen articles. The review explores postoperative pain management in oral cancer patients; highlighting persistent opioid use; the efficacy of adjuvant drugs, such as gabapentin; and a multimodal approach. It emphasizes the need for personalized pain management, recognizing individual pain perception and tailoring interventions. Integrating pharmacological and non-pharmacological strategies is crucial for comprehensive pain management. The review also serves as a guide for future research, emphasizing the need for standardized methodologies and diverse participant populations.