%0 Journal Article
%T Gut microbiota and its relationship with early vascular ageing in a Spanish population (MIVAS study).
%A Salvado R
%A Santos-Minguez S
%A Lugones-Sánchez C
%A Gonzalez-Sánchez S
%A Tamayo-Morales O
%A Quesada-Rico JA
%A Benito R
%A Rodríguez-Sánchez E
%A Gómez-Marcos MA
%A Casado-Vicente V
%A Guimarães-Cunha P
%A Hernandez-Rivas JM
%A Mira A
%A García-Ortiz L
%A  
%J Eur J Clin Invest
%V 0
%N 0
%D 2024 Apr 24
%M 38655910
%F 5.722
%R 10.1111/eci.14228
%X <B>BACKGROUND: </B>Gut microbiota and its by-products are increasingly recognized as having a decisive role in cardiovascular diseases. The aim is to study the relationship between gut microbiota and early vascular ageing (EVA).<BR><B>METHODS: </B>A cross-sectional study was developed in Salamanca (Spain) in which 180 subjects aged 45-74 years were recruited. EVA was defined by the presence of at least one of the following: carotid-femoral pulse wave velocity (cf-PWV), cardio-ankle vascular index (CAVI) or brachial-ankle pulse wave velocity (ba-PWV) above the 90th percentile of the reference population. All other cases were considered normal vascular ageing (NVA).<BR><B>METHODS: </B>cf-PWV was measured by SphygmoCor® System; CAVI and ba-PWV were determined by Vasera 2000® device. Gut microbiome composition in faecal samples was determined by 16S rRNA Illumina sequencing.<BR><B>RESULTS: </B>Mean age was 64.4 ± 6.9 in EVA group and 60.4 ± 7.6 years in NVA (p < .01). Women in EVA group were 41% and 53% in NVA. There were no differences in the overall composition of gut microbiota between the two groups when evaluating Firmicutes/Bacteriodetes ratio, alfa diversity (Shannon Index) and beta diversity (Bray-Curtis). Bilophila, Faecalibacterium sp.UBA1819 and Phocea, are increased in EVA group. While Cedecea, Lactococcus, Pseudomonas, Succiniclasticum and Dielma exist in lower abundance. In logistic regression analysis, Bilophila (OR: 1.71, 95% CI: 1.12-2.6, p = .013) remained significant.<BR><B>CONCLUSIONS: </B>In the studied Spanish population, early vascular ageing is positively associated with gut microbiota abundance of the genus Bilophila. No relationship was found between phyla abundance and measures of diversity.