%0 Journal Article
%T Donor Lung Preservation at 10°C: Clinical and Logistical Impact.
%A Gil Barturen M
%A Laporta Hernández R
%A Romero Berrocal A
%A Pérez Redondo M
%A Gómez Lozano N
%A Martín López J
%A Royuela Vicente A
%A Romero Román A
%A Hoyos Mejía L
%A Crowley Carrasco S
%A Gómez de Antonio D
%A Naranjo Gómez JM
%A Córdoba Peláez M
%A Novoa NM
%A Campo-Cañaveral de la Cruz JL
%J Arch Bronconeumol
%V 60
%N 6
%D 2024 Jun 6
%M 38644153
%F 6.333
%R 10.1016/j.arbres.2024.03.021
%X <B>BACKGROUND: </B>Cold static donor lung preservation at 10°C appears to be a promising method to safely extend the cold ischemic time (CIT) and improve lung transplant (LTx) logistics.<BR><B>METHODS: </B>LTx from November 2021 to February 2023 were included in this single institution, prospective, non-randomized study comparing prolonged preservation at 10°C versus standard preservation on ice. The inclusion criteria for 10°C preservation were suitable grafts for LTx without any donor retrieval concerns.<BR><B>METHODS: </B>primary graft dysfunction (PGD) grade-3 at 72-h. Secondary endpoints: clinical outcomes, cytokine profile and logistical impact.<BR><B>RESULTS: </B>Thirty-three out of fifty-seven cases were preserved at 10°C. Donor and recipient characteristics were similar across the groups. Total preservation times (h:min) were longer (p<0.001) in the 10°C group [1st lung: median 12:09 (IQR 9:23-13:29); 2nd: 14:24 (12:00-16:20)] vs. standard group [1st lung: median 5:47 (IQR 5:18-6:40); 2nd: 7:15 (6:33-7:40)]. PGD grade-3 at 72-h was 9.4% in 10°C group vs. 12.5% in standard group (p=0.440). Length of mechanical ventilation (MV), ICU and hospital stays were similar in both groups. Thirty and ninety-day mortality rates were 0% in 10°C group (vs. 4.2% in standard group). IL-8 concentration was significantly higher 6-h post-LTx in the standard group (p=0.025) and IL-10 concentration was increased 72-h post-LTx in the 10°C group (p=0.045).<BR><B>CONCLUSIONS: </B>Preservation at 10°C may represent a safe and feasible strategy to intentionally prolong the CIT. In our center, extending the CIT at 10°C may allow for semi-elective LTx and improve logistics with similar outcomes compared to the current standard preservation on ice.