%0 Journal Article
%T Minimum information and guidelines for reporting a multiplexed assay of variant effect.
%A Claussnitzer M
%A Parikh VN
%A Wagner AH
%A Arbesfeld JA
%A Bult CJ
%A Firth HV
%A Muffley LA
%A Nguyen Ba AN
%A Riehle K
%A Roth FP
%A Tabet D
%A Bolognesi B
%A Glazer AM
%A Rubin AF
%J Genome Biol
%V 25
%N 1
%D 2024 04 19
%M 38641812
暂无%R 10.1186/s13059-024-03223-9
%X Multiplexed assays of variant effect (MAVEs) have emerged as a powerful approach for interrogating thousands of genetic variants in a single experiment. The flexibility and widespread adoption of these techniques across diverse disciplines have led to a heterogeneous mix of data formats and descriptions, which complicates the downstream use of the resulting datasets. To address these issues and promote reproducibility and reuse of MAVE data, we define a set of minimum information standards for MAVE data and metadata and outline a controlled vocabulary aligned with established biomedical ontologies for describing these experimental designs.