%0 Systematic Review
%T Helminth-derived proteins as immune system regulators: a systematic review of their promise in alleviating colitis.
%A Alghanmi M
%A Minshawi F
%A Altorki TA
%A Zawawi A
%A Alsaady I
%A Naser AY
%A Alwafi H
%A Alsulami SM
%A Azhari AA
%A Hashem AM
%A Alhabbab R
%J BMC Immunol
%V 25
%N 1
%D 2024 Apr 18
%M 38637733
%F 3.594
%R 10.1186/s12865-024-00614-2
%X Helminth-derived proteins have immunomodulatory properties, influencing the host's immune response as an adaptive strategy for helminth survival. Helminth-derived proteins modulate the immune response by inducing anti-inflammatory cytokines, promoting regulatory T-cell development, and ultimately favouring a Th2-biased immune response. This systematic review focused on helminth-derived proteins and explored their impact on reducing inflammatory responses in mouse models of colitis. A systematic search across Medline, EMBASE, Web of Science, and Cochrane Library identified fourteen relevant studies. These studies reported immunomodulatory changes, including increased production of anti-inflammatory cells and cytokines. In mouse models of colitis treated with on helminth-derived proteins, significant improvements in pathological parameters such as body weight, colon length, and microscopic inflammatory scores were observed compared to control groups. Moreover, helminth-derived proteins can enhance the function of Tregs and alleviate the severity of inflammatory conditions. The findings underscore the pivotal role of helminth-derived proteins in immunomodulation, specifically in the axis of cytokine secretion and immune cell polarization. The findings offer new opportunities for treating chronic inflammatory conditions such Crohn's disease.