%0 Journal Article
%T Clinical spectrum and outcome of Takayasu's arteritis in children.
%A Hassold N
%A Dusser P
%A Laurent A
%A Lemelle I
%A Pillet P
%A Comarmond C
%A Mekinian A
%A Lambert M
%A Mirault T
%A Benhamou Y
%A Belot A
%A Jeziorski E
%A Reumaux H
%A Sibilia J
%A Desdoits A
%A Espitia O
%A Faye A
%A Quartier P
%A Saadoun D
%A Koné-Paut I
%J Joint Bone Spine
%V 91
%N 5
%D 2024 Apr 15
%M 38631524
%F 5.263
%R 10.1016/j.jbspin.2024.105735
%X <B>OBJECTIVE: </B>We aimed to compare clinical spectrum and outcome between adults and children with Takayasu's arteritis (TAK) in a European population.<BR><B>METHODS: </B>We made a nationwide retrospective observational study between 1988 and 2019. All adult patients met the ACR diagnostic criteria for TAK and all children met the EULAR/PRINTO/PRES criteria for paediatric TAK.<BR><B>RESULTS: </B>We identified 46 children and 389 adults with TAK. The male to female ratio was 34/46 (0.74) in the paediatric group compared to 241/274 (0.88) in the adult group (P<0.05). Children presented with significantly more systemic symptoms; i.e., fever (P<0.05), fatigue (P<0.001), weight loss (P<0.001), abdominal pain (P<0.05), and myalgia (P<0.05) while adults had more upper limb claudication (P<0.01). Topography of the lesions differed significantly between the two groups: adults had more damage at the cerebral vasculature (P<0.01), upper and lower limbs (P<0.001) while children had more kidney lesions (P<0.05). Children TAK had more frequent (P<0.01) and higher (P<0.001) biological inflammation than adults. Children received higher dose-weight of corticosteroids (P=0.001) and less biotherapy (P<0.010) at diagnosis. Relapses (P<0.05) and death (8.6% vs 4.9%) were more frequent in children TAK than in adults.<BR><B>CONCLUSIONS: </B>Paediatric TAK seems more severe than adult TAK. Therefore, paediatrics patients may require closer monitoring and systemic use of biological treatment.