%0 Journal Article
%T Anti-trypanosomal Lignans Isolated from Salvadoran Peperomia pseudopereskiifolia.
%A Castillo UG
%A Uekusa Y
%A Nishimura T
%A Kiuchi F
%A Martínez ML
%A Menjívar J
%A Nakajima-Shimada J
%A Núñez MJ
%A Kikuchi H
%J J Nat Prod
%V 87
%N 4
%D 2024 Apr 26
%M 38631020
%F 4.803
%R 10.1021/acs.jnatprod.4c00022
%X A search for anti-trypanosomal natural compounds from plants collected in El Salvador, a country particularly endemic for Chagas disease, resulted in the isolation of five lignan-type compounds (1-5) from Peperomia pseudopereskiifolia. The lignan derivatives 1, 2, and 4 are new. Their absolute configuration was determined by chemical derivatization. Compounds 1, 5, 6, and 8 exhibited anti-trypanosomal activity against the amastigote form of T. cruzi comparable to that of the existing drug benznidazole.