%0 Journal Article
%T PLK3 is linked with higher tumor stage and unfavorable prognosis in patients with colorectal cancer.
%A Zeng H
%A Wang Q
%A Xiang Y
%A Yang Y
%A Tu X
%A He H
%A Li S
%A Zhang W
%J Biomark Med
%V 18
%N 6
%D 2024 Apr 17
%M 38629862
%F 2.498
%R 10.2217/bmm-2023-0591
%X Objective: This study intended to explore the relationship of PLK3 with prognosis in patients with colorectal cancer (CRC). Methods: PLK3 positivity was detected by immunohistochemistry in 160 patients with CRC receiving surgical resection. Results: The median tumor PLK3-positive rate was 26.5%. Tumor PLK3-positive rate was related to increased lymph node stage (p = 0.002) and tumor-node-metastasis stage (p < 0.001) of CRC. Tumor PLK3-positive rate ≥30% was related to shortened disease-free survival (p = 0.009) and overall survival (p = 0.003); tumor PLK3-positive rate ≥50% showed a stronger correlation with them (both p = 0.001), which was validated by multivariate Cox regression analyses (both p < 0.05). Conclusion: Tumor PLK3-positive rate ≥50% relates to increased tumor stage and unfavorable survival in patients with CRC.<BR>[Box: see text].