%0 Journal Article
%T Radiation-induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report.
%A Takahashi-Watanabe M
%A Fujimura T
%A Amagai R
%A Ohuchi K
%A Yamazaki E
%A Tamabuchi E
%A Kuroki S
%A Kambayashi Y
%A Hashimoto A
%A Asano Y
%J J Dermatol
%V 0
%N 0
%D 2024 Apr 17
%M 38629702
%F 3.468
%R 10.1111/1346-8138.17221
%X Cutaneous squamous cell carcinoma (cSCC) arising from radiation dermatitis has a higher risk of metastasis than conventional cSCC. Immunosuppression is another risk factor for cSCC, suggesting that mycosis fungoides (MF) could be a risk factor for cSCC. Here we report a case of radiation-induced cSCC with a high level of tumor-mutation burden that developed in a patient with MF who was successfully treated with pembrolizumab. The present case suggests that pembrolizumab might be an optimal therapy for radiation-induced cSCC, even at advanced stages.