%0 Journal Article
%T Efficacy and Safety of Tinzaparin Thromboprophylaxis in Lung Cancer Patients with High Thromboembolic Risk: A Prospective, Observational, Single-Center Cohort Study.
%A Kouvela M
%A Livanou ME
%A Stefanou DT
%A Vathiotis IA
%A Sarropoulou F
%A Grammoustianou M
%A Dimakakos E
%A Syrigos N
%J Cancers (Basel)
%V 16
%N 7
%D 2024 Apr 8
%M 38611118
%F 6.575
%R 10.3390/cancers16071442
%X <B>BACKGROUND: </B>The aim of this study was to record and assess the efficacy and safety ofthromboprophylaxis with an intermediate dose of Tinzaparin in lung cancer patients with high thrombotic risk.<BR><B>METHODS: </B>This was a non-interventional, single-arm, prospective cohort study of lung cancer patients who received thromboprophylaxis with Tinzaparin 10.000 Anti-Xa IU in 0.5 mL, OD, used in current clinical practice. Enrolled ambulatory patients signed informed consent. Anti-Xa levels were tested.<BR><B>RESULTS: </B>In total, 140 patients were included in the study, of which 81.4% were males. The histology of the tumor was mainly adenocarcinoma. Lung cancer patients with high thrombotic risk based on tumor, patient, treatment, and laboratory-related factors were enrolled. Only one patient experienced a thrombotic event (0.7%), and 10 patients had bleeding events (7.1%), including only one major event. Anti-Xa levels measured at 10 days and 3 months did not differ significantly between patients who developed hemorrhagic events and those who did not (p = 0.26 and p = 0.32, respectively).<BR><B>CONCLUSIONS: </B>Thromboprophylaxis with an intermediate Tinzaparin dose in high thrombotic-risk lung cancer patients is a safe and effective choice for the prevention of VTE.