%0 Journal Article %T Development and Application of the Novel Plant Growth Regulator Guvermectin: A Perspective. %A Liu C %A Zhang M %A Li L %A Wang X %A Li S %A Xiang W %J J Agric Food Chem %V 72 %N 15 %D 2024 Apr 17 %M 38588402 %F 5.895 %R 10.1021/acs.jafc.3c09704 %X Plant growth regulators (PGRs) play an important role in alleviating the detrimental effects of biotic and abiotic stress and improving crop yield and quality. As a novel PGR from Streptomyces registered in 2021, guvermectin (GV) has the potential to improve plant yield and defense, making its application in agriculture a subject of interest. Here, we describe the discovery process, functional activities, agricultural applications, toxicity, environmental safety, and biosynthetic mechanism of GV. This Perspective provides a guide for the development of novel PGRs from microorganisms.