%0 Case Reports
%T Detection of 4p16.3 deletion and 11p15.5p15.4 gain in a boy by comparative genomic hybridization array: A case report.
%A Kaya I
%J World J Clin Cases
%V 12
%N 8
%D 2024 Mar 16
%M 38576798
%F 1.534
%R 10.12998/wjcc.v12.i8.1517
%X <B>BACKGROUND: </B>Nonallelic homologous recombination (NAHR) of segmental duplications or low copy repeats (LCRs) result in DNA gain/loss and play an important role in the origin of genomic disorders.<BR><B>METHODS: </B>A 3-year- old boy was referred for genetic analysis. Comparative genomic hybridization array analysis revealed a loss of 3776 kb in the 4p16.3 chromosomal region and a gain of 3201 kb in the 11p15.5p15.4 chromosomal region.<BR><B>CONCLUSIONS: </B>Genomic imbalances caused by NAHR in LCRs result in deletion and duplication syndromes.