%0 Journal Article
%T Role of CD34-immunopositive Microvascular Density in Juvenile Nasopharyngeal Angiofibroma.
%A Jaiswal AS
%A Kumar R
%A Kakkar A
%A Kumar R
%A Verma H
%A Bhalla AS
%A Kairo AK
%A Thakar A
%J Indian J Otolaryngol Head Neck Surg
%V 76
%N 2
%D 2024 Apr
%M 38566736
暂无%R 10.1007/s12070-023-04331-x
%X <B>UNASSIGNED: </B>To assess the microvascular density (MVD) in juvenile nasopharyngeal angiofibroma (JNA) with CD34 immunostaining and evaluate its relationship with clinico-demographic features.<BR><B>UNASSIGNED: </B>This prospective study included patients with JNA undergoing endoscopic excision. The histopathological specimen was stained using CD-34 antibodies to calculate MVD. MVD and clinico-demographic features were correlated.<BR><B>UNASSIGNED: </B>The study included 12 patients with a median age of 15.5 years. The mean MVD was 39 vessels/high power field (range 5 to 151 vessels). MVD was significantly associated only with the volume of tumour (r = 0.65, p = 0.02). The recurrence occurred in one patient with an MVD of 107. The median follow-up was 38 months.<BR><B>UNASSIGNED: </B>MVD is significantly associated with tumour volume in JNA, which implies a robust role of angiogenesis in the pathology of the tumour. Also, higher MVD may be a risk factor for recurrence.