%0 Journal Article
%T Assessment for Carotid Atherosclerotic Plaque Using Vessel Wall Magnetic Resonance Imaging: A Multireader ROC Study to Determine Optimal Sequence for Detecting Vessel Wall Calcification.
%A Ishimaru H
%A Ikebe Y
%A Izumo T
%A Imai H
%A Morikawa M
%A Ideguchi R
%A Ishiyama A
%A Koike H
%A Uetani M
%A Toya R
%J J Vasc Res
%V 61
%N 3
%D 2024 Mar 28
%M 38547846
%F 2.045
%R 10.1159/000538175
%X <B>BACKGROUND: </B>We aimed to compare conventional vessel wall MR imaging techniques and quantitative susceptibility mapping (QSM) to determine the optimal sequence for detecting carotid artery calcification.<BR><B>METHODS: </B>Twenty-two patients who underwent carotid vessel wall MR imaging and neck CT were enrolled. Four slices of 6-mm sections from the bilateral internal carotid bifurcation were subdivided into 4 segments according to clock position (0-3, 3-6, 6-9, and 9-12) and assessed for calcification. Two blinded radiologists independently reviewed a total of 704 segments and scored the likelihood of calcification using a 5-point scale on spin-echo imaging, FLASH, and QSM. The observer performance for detecting calcification was evaluated by a multireader, multiple-case receiver operating characteristic study. Weighted κ statistics were calculated to assess interobserver agreement.<BR><B>RESULTS: </B>QSM had a mean area under the receiver operating characteristic curve of 0.85, which was significantly higher than that of any other sequence (p &lt; 0.01) and showed substantial interreader agreement (κ = 0.68). A segment with a score of 3-5 was defined as positive, and a segment with a score of 1-2 was defined as negative; the sensitivity and specificity of QSM were 0.75 and 0.87, respectively.<BR><B>CONCLUSIONS: </B>QSM was the most reliable MR sequence for the detection of plaque calcification.