%0 Journal Article %T Cracking the NLRP3 code: Pioneering precision medicine for inflammation. %A Weber ANR %A Tortola MM %A Kuemmerle-Deschner JB %J J Exp Med %V 221 %N 5 %D 2024 May 6 %M 38536100 %F 17.579 %R 10.1084/jem.20240221 %X Precisely diagnosing and effectively treating cryopyrin-associated periodic syndrome (CAPS), an inflammatory condition linked to gain-of-function NLRP3 inflammasome mutations, poses challenges. A novel classification approach may help inform therapeutic decisions and offer valuable insights into broader inflammatory conditions (Cosson et al. J. Exp. Med. 2024. https://doi.org/10.1084/jem.20231200).