%0 Journal Article
%T Visit to visit transition in TXNIP gene methylation and the risk of type 2 diabetes mellitus: a nested case-control study.
%A Wu Y
%A Chen W
%A Zhao Y
%A Gu M
%A Gao Y
%A Ke Y
%A Wang L
%A Wang M
%A Zhang W
%A Chen Y
%A Huo W
%A Fu X
%A Li X
%A Zhang D
%A Qin P
%A Hu F
%A Liu Y
%A Sun X
%A Zhang M
%A Hu D
%J J Hum Genet
%V 69
%N 7
%D 2024 Jul 25
%M 38528048
%F 3.755
%R 10.1038/s10038-024-01243-8
%X Our study aimed to investigate the association between the transition of the TXNIP gene methylation level and the risk of incident type 2 diabetes mellitus (T2DM). This study included 263 incident cases of T2DM and 263 matched non-T2DM participants. According to the methylation levels of five loci (CpG1-5; chr1:145441102-145442001) on the TXNIP gene, the participants were classified into four transition groups: maintained low, low to high, high to low, and maintained high methylation levels. Compared with individuals whose methylation level of CpG2-5 at the TXNIP gene was maintained low, individuals with maintained high methylation levels showed a 61-87% reduction in T2DM risk (66% for CpG2 [OR: 0.34, 95% CI: 0.14, 0.80]; 77% for CpG3 [OR: 0.23, 95% CI: 0.07, 0.78]; 87% for CpG4 [OR: 0.13, 95% CI: 0.03, 0.56]; and 61% for CpG5 [OR: 0.39, 95% CI: 0.16, 0.92]). Maintained high methylation levels of four loci of the TXNIP gene are associated with a reduction of T2DM incident risk in the current study. Our study suggests that preserving hypermethylation levels of the TXNIP gene may hold promise as a potential preventive measure against the onset of T2DM.