%0 Journal Article
%T Association between Portal Vein Thrombosis after Umbilical Vein Catheterization and Neonatal Asphyxia.
%A Colella M
%A Zanin A
%A Toumazi A
%A Bourmaud A
%A Boizeau P
%A Guilmin-Crepon S
%A Leick N
%A Khat S
%A Alison M
%A Baud O
%A Biran V
%J Neonatology
%V 121
%N 4
%D 2024 Mar 22
%M 38522417
%F 5.106
%R 10.1159/000537902
%X <B>BACKGROUND: </B>Neonatal portal vein thrombosis (PVT) is frequently related to umbilical venous catheterization (UVC), but risk factors remain unclear. This study aims to analyze the variables associated to PVT in near- to full-term newborns with UVC, with a focus on newborns exposed to controlled therapeutic hypothermia (CTH) for hypoxic ischemic encephalopathy (HIE).<BR><B>METHODS: </B>This is retrospective cohort study of infants delivered at or after 36 weeks and with a birthweight over 1,500 g. All infants were assessed for UVC location and PVT using ultrasonography performed between day 5 and day 10 after catheterization.<BR><B>RESULTS: </B>Among 213 eligible patients, PVT was diagnosed in 57 (27%); among them, 54 (95%) were localized in the left portal vein branch. With all significant factors in univariate analysis considered, higher gestational age at birth (adjusted OR 1.35; 95% CI: 1.12-1.64, p = 0.002) and duration of UVC placement (adjusted OR 1.36; 95% CI: 1.11-1.67, p = 0.004) were the main risk factors of PVT. Among 87 infants who were cooled for HIE, 31 (36%) had PVT compared to 26 (21%) in infants without CTH. Using a multivariate model including variables linked to treatment procedures only, an increased PVT incidence was statistically associated with UVC duration (adjusted OR 1.33; 95% CI: 1.08; 1.63, p = 0.01) and CTH (adjusted OR 1.94; 95% CI: 1.04-3.65, p = 0.04).<BR><B>CONCLUSIONS: </B>Left PVT was frequently observed in near- to full-term neonates with UVC. Among factors linked to treatment procedures, both duration of UVC and CTH exposure for HIE were found to be independent risk factors of PVT.