%0 Journal Article
%T Efficacy, safety, and tolerability of xanomeline for schizophrenia spectrum disorders: a systematic review.
%A Leber A
%A Ramachandra R
%A Ceban F
%A Kwan ATH
%A Rhee TG
%A Wu J
%A Cao B
%A Jawad MY
%A Teopiz KM
%A Ho R
%A Le GH
%A Ramachandra D
%A McIntyre RS
%J Expert Opin Pharmacother
%V 25
%N 4
%D 2024 Mar 27
%M 38515004
%F 4.103
%R 10.1080/14656566.2024.2334424
%X <B>UNASSIGNED: </B>We systematically reviewed extant studies evaluating the efficacy and tolerability of xanomeline and xanomeline-trospium (KarXT) for treatment of adults with schizophrenia.<BR><B>UNASSIGNED: </B>In accordance with PRISMA guidelines, articles were systematically searched for in databases and clinical trial registries.<BR><B>UNASSIGNED: </B>A total of 4 preclinical trials and 3 randomized controlled trials (RCTs) were included in this review. A 4-week RCT observed a difference of 24.0 points (SD 21.0) in the Positive and Negative Syndrome Scale (PANSS) total score between xanomeline and placebo groups (p = 0.039). A 5-week RCT observed PANSS total score changes from baseline to week 5, including -17.4 and -5.9 points in KarXT and placebo groups, respectively (LSMD -11.6 points; 95% CI -16.1 to -7.1; p < 0.001; d = 0.75). Another 5-week RCT observed PANSS total score changes from baseline to week 5, including -21.2 (SE 1.7) and -11.6 (SE 1.6) points in KarXT and placebo groups, respectively (LSMD -9.6; 95% CI -13.9 to -5.2; p < 0.0001; d = 0.61). Side effects include constipation, nausea, vomiting, dyspepsia, and dry mouth.<BR><B>UNASSIGNED: </B>KarXT offers an innovative non-D2 blocking approach, representing a promising treatment avenue for schizophrenia.