%0 Journal Article
%T Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development.
%A Zhang J
%A Zhao W
%A Zhou Y
%A Xi S
%A Xu X
%A Du X
%A Zheng X
%A Hu W
%A Sun R
%A Tian Z
%A Fu B
%A Wei H
%J Cell Rep Med
%V 5
%N 3
%D 2024 Mar 19
%M 38508138
%F 16.988
%R 10.1016/j.xcrm.2024.101476
%X Endometriosis, affecting 6%-10% of women, often leads to pain and infertility and its underlying inflammatory mechanisms are poorly understood. We established endometriosis models in wild-type and IL16KO mice, revealing the driver function of IL-16 in initiating endometriosis-related inflammation. Using an in vitro system, we confirmed iron overload-induced GSDME-mediated pyroptosis as a key trigger for IL-16 activation and release. In addition, our research led to the development of Z30702029, a compound inhibiting GSDME-NTD-mediated pyroptosis, which shows promise as a therapeutic intervention for endometriosis. Importantly, our findings extend beyond endometriosis, highlighting GSDME-mediated pyroptosis as a broader pathway for IL-16 release and offering insights into potential treatments for various inflammatory conditions.