%0 Journal Article
%T Translating NIA-AA criteria into usual practice: Report from the ReDeMa Project.
%A Sánchez-Soblechero A
%A Berbel A
%A Villarejo A
%A Palmí-Cortés I
%A Vieira A
%A Gil-Moreno MJ
%A Fernández C
%A Martín-Montes Ã
%A Carreras MT
%A Fernández Y
%A Puertas C
%A Blanco-Palmero V
%A Llamas S
%A González-Sánchez M
%A Lapeña T
%A de Luis P
%A Manzano S
%A Olazarán J
%J Alzheimers Dement (N Y)
%V 10
%N 1
%D 2024 Jan-Mar
%M 38505833
暂无%R 10.1002/trc2.12451
%X <B>BACKGROUND: </B>Biomarker-informed criteria were proposed for the diagnosis of Alzheimer's disease (AD) by the National Institute on Aging and the Alzheimer's Association (NIA-AA) in 2011; however, the adequacy of this criteria has not been sufficiently evaluated.<BR><B>METHODS: </B>ReDeMa (Red de Demencias de Madrid) is a regional cohort of patients attending memory and neurology clinics. Core cerebrospinal fluid biomarkers were obtained, NIA-AA diagnostic criteria were considered, and changes in diagnosis and management were evaluated.<BR><B>RESULTS: </B>A total of 233 patients were analyzed (mean age 70 years, 50% women, 73% AD). The diagnostic language was modified significantly, with a majority assumption of NIA-AA definitions (69%). Confidence in diagnosis increased from 70% to 92% (p < 0.0005) and management was changed in 71% of patient/caregivers. The influence of neurologist's age or expertise on study results was minimal.<BR><B>CONCLUSIONS: </B>The NIA-AA criteria are adequate and utile for usual practice in memory and neurology clinics, improving diagnostic confidence and significantly modifying patient management.<BR><B>CONCLUSIONS: </B>Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers increase diagnostic certainty regardless of the neurologist.AD CSF biomarkers lead to changes in disease management .Biomarker-enriched, 2011 NIA-AA diagnostic criteria are adequate for usual practice.