%0 Journal Article
%T Association between dietary calcium to Phosphorus Ratio and the odds of ulcerative colitis: A case-control study.
%A Tangestani H
%A Jamshidi A
%A Yari Z
%A Jalaliyan Z
%A Ghalandari H
%A Hekmatdoost A
%A Rashvand S
%A Mohammadi Baghmolae A
%A Emamat H
%J Heliyon
%V 10
%N 6
%D 2024 Mar 30
%M 38500985
%F 3.776
%R 10.1016/j.heliyon.2024.e27556
%X <B>UNASSIGNED: </B>Ulcerative colitis (UC) is a recurrent, inflammatory, autoimmune intestinal disease. The dietary calcium to phosphorus (Ca:P) ratio is suggested to affect the inividuals' normal metabolic and inflammatory pathways. The present study aimed to investigate the association between dietary Ca:P ratio and the odds of developing UC in a case-control format.<BR><B>UNASSIGNED: </B>The study included sixty-two currently diagnosed UC patients and one hundred twenty-four matched controls, designed as a case-control study. The dietary intakes of the participants were assessed by a food frequency questionnaire (FFQ), and the dietary Ca:P ratio was calculated. The association between tertiles of Ca:P ratio and UC was examined using the logistic regression. P-values <0.05 were considered as significant.<BR><B>UNASSIGNED: </B>The study sample consisted of participants with an average age of 36.63 ± 12.42 years and a mean body mass index (BMI) of 25.39 ± 3.82 kg/m2. The overall energy-adjusted ratio of Ca:P was 0.74 ± 0.11. In the multivariate model, after adjustment for potential confounders, participants in the third tertile of dietary Ca:P ratio had a lower odds of developing UC compared to the lowest tertlie (OR: 0.34, 95% CI: 0.13-0.87; p = 0.026).<BR><B>UNASSIGNED: </B>Our results indicate that a higher ratio of dietary Ca:P ratio might be protective against developing UC. However, further studies are warranted to examine this association in various populations.