%0 News
%T Measuring Objective and Subjective Sleep during Lisdexamfetamine Treatment of Acute Methamphetamine Withdrawal: A Feasibility Study.
%A Acheson LS
%A Gordon C
%A McKetin R
%A Brett J
%A Christmass M
%A Rodgers C
%A Lintzeris N
%A Dunlop A
%A Farrell M
%A Shoptaw S
%A Ezard N
%A Siefried KJ
%J Eur Addict Res
%V 30
%N 2
%D 2024 Mar 18
%M 38498995
%F 4
%R 10.1159/000536328
%X <B>BACKGROUND: </B>Sleep disturbance is common during methamphetamine (MA) use and withdrawal; however, the feasibility of combined subjective-objective measurement of sleep-wake has not been shown in this population. Actigraphy is a well-established, non-invasive measure of sleep-wake cycles with good concordance with polysomnography. This study aimed to investigate the feasibility and utility of using actigraphy and sleep diaries to investigate sleep during MA withdrawal.<BR><B>METHODS: </B>We conducted a feasibility and utility study of actigraphy and sleep diaries during a clinical trial of lisdexamfetamine for MA withdrawal. Participants were inpatients for 7 days, wore an actigraph (Philips Actiwatch 2) and completed a modified Consensus Sleep Diary each morning. Participants were interviewed between days 3-5.<BR><B>RESULTS: </B>Ten participants (mean age 37 years, 90% male) were enrolled. No participant removed the device prematurely. Participants interviewed (n = 8) reported that the actigraph was not difficult or distracting to wear or completion of daily sleep diary onerous. Actigraphic average daily sleep duration over 7 days was 568 min, sleep onset latency 22.4 min, wake after sleep onset (WASO) 75.2 min, and sleep efficiency 83.6%. Sleep diaries underreported daily sleep compared with actigraphy (sleep duration was 56 min (p = 0.008) and WASO 47 min (p &lt; 0.001) less). Overall sleep quality was 4.4 on a nine-point Likert scale within the diary.<BR><B>CONCLUSIONS: </B>Continuous actigraphy is feasible to measure sleep-wake in people withdrawing from MA, with low participant burden. We found important differences in self-reported and actigraphic sleep, which need to be explored in more detail.