%0 Meta-Analysis
%T Prevalence of linezolid resistance in Streptococcus pneumoniae isolates: a systematic review and meta-analysis.
%A Heidary M
%A Dashtbin S
%A Asadi A
%A Asadollahi P
%A Khatib A
%A Ebrahimi MA
%A Ghanbari Z
%A Darbandi A
%A Ghanavati R
%A Pakzad R
%J Future Microbiol
%V 19
%N 0
%D 2024 03 18
%M 38497912
%F 3.553
%R 10.2217/fmb-2023-0170
%X Aim: This study aimed to understand the current level of linezolid (LNZ) resistance in Streptococcus pneumoniae isolates reported over the past 10 years. Material & methods: An electronic search was conducted for the following keywords: ((Streptococcus pneumoniae [title/abstract]) OR (Pneumococcus [title/abstract]) OR (Pneumococci [title/abstract]) AND (linezolid [title/abstract]) OR (Zyvox [title/abstract])) OR (Zyvoxid [title/abstract])). Result: Out of all the studies, 80 had a cross-sectional design, while 11 followed a cohort approach. The prevalence of LNZ resistance among S. pneumoniae isolates ranged from 0% to 4.86%. Discussion: Urgent, high-powered, randomized, controlled trials with participants from endemic regions are needed to gain a comprehensive understanding of the impact on and significance of LNZ treatment to patients.