%0 Journal Article
%T Synthesis and evaluation of amylose-mefenamic acid conjugates as colon-targeting prodrugs.
%A Chugh S
%A Sharma M
%A Mudila H
%A Prasher P
%J Ther Deliv
%V 0
%N 0
%D 2024 Mar 18
%M 38497152
暂无%R 10.4155/tde-2023-0106
%X Aim: Amide-linked amylose-based prodrugs were developed for colon-targeted release of mefenamic acid. Materials & methods: Activation of prodrug was studied spectrophotometrically, enzyme-linked immunosorbent assay appraised cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inhibition at different concentrations of the prodrug, the behavior of prodrug under physiological conditions was monitored by scanning electron microscopy. Results: Prodrug was poorly activated in the enzyme-free simulated gastric media and simulated intestinal media (SIM) but preincubation in pancreatin followed by treatment in aminopeptidase containing SIM led to a significant activation of prodrug. Conclusion: Amide-linked amylose-mefenamic acid conjugates showed a slow release in simulated gastric media and a controlled release in SIM with pancreatin playing an important role in drug release.