%0 Journal Article
%T Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion.
%A Zhang H
%A Li Y
%A Ibáñez CF
%A Xie M
%J Elife
%V 13
%N 0
%D 2024 Mar 12
%M 38470102
%F 8.713
%R 10.7554/eLife.93151
%X Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence of a distinct subpopulation of Ucp1-&Cidea+ adipocytes that arises from brown-to-white conversion during postnatal life in the periureter region of mouse PRAT. Cold exposure restores Ucp1 expression and a thermogenic phenotype in this subpopulation. These cells have a transcriptome that is distinct from subcutaneous beige adipocytes and may represent a unique type of cold-recruitable adipocytes. These results pave the way for studies of PRAT physiology and mechanisms controlling the plasticity of brown/white adipocyte phenotypes.