%0 Journal Article
%T Description of a national, multi-center registry of patients with sickle cell disease and SARS-CoV-2 infection: Data from the Pediatric COVID-19 United States Registry.
%A Dain AS
%A Diorio C
%A Fisher BT
%A Hankins JS
%A Witmer CM
%A Boustany M
%A Burton M
%A Ferrolino J
%A Sadaf S
%A Ross HS
%A Maron G
%A  
%J Pediatr Blood Cancer
%V 71
%N 6
%D 2024 Jun 12
%M 38469996
%F 3.838
%R 10.1002/pbc.30909
%X Children with sickle cell disease (SCD) are at risk of complications from viral infections, including SARS-CoV-2. We present the clinical characteristics and outcomes of pediatric patients with SCD from the Pediatric COVID-19 United States Registry who developed acute COVID-19 due to SARS-CoV-2 infection (n = 259) or multisystem inflammatory syndrome in children (MIS-C; n = 4). Nearly half of hospitalized children with SCD and SARS-CoV-2 infection required supplemental oxygen, though children with SCD had fewer intensive care (ICU) admissions compared to the general pediatric and immunocompromised populations. All registry patients with both SCD and MIS-C required ICU admission. Children with SCD are at risk of severe disease with SARS-CoV-2 infection, highlighting the importance of vaccination in this vulnerable population.