%0 Journal Article
%T Short-term effect of intravitreal dexamethasone implant in refractory diabetic macular edema.
%A Moreno JB
%A Medina DB
%A Rosellón-Escobar MF
%A García-Aguirre JG
%J BMC Ophthalmol
%V 24
%N 1
%D 2024 Mar 11
%M 38462613
%F 2.086
%R 10.1186/s12886-024-03341-9
%X <B>OBJECTIVE: </B>To evaluate the short-term effects (hours-days) of intravitreal dexamethasone implant (IDI) in eyes with diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (VEGF) injections.<BR><B>METHODS: </B>This was a prospective, single-arm, interventional clinical series. Eyes with DME and 3-9 injections of ranibizumab without a good response were included. Patients underwent a single IDI. Best-corrected visual acuity (BCVA) measurement, complete ophthalmic evaluation, and spectral-domain optical coherence tomography (SD-OCT) were performed at baseline, 2 h, 3 h, 24 h, 7 days, and 1 month. The main outcomes were change in central retinal thickness (CRT) on SD-OCT and BCVA.<BR><B>RESULTS: </B>Fifteen eyes of 15 patients were included. Mean CRT decreased after treatment from 515.87 µm ± 220.00 µm at baseline to 489.60 µm ± 176.53 µm after 2 h (p = 0.126), and 450.13 µm ± 163.43 at 24 h (p = 0.006). Change in BCVA was from 0.85 ± 0.44 logMAR baseline to 0.58 ± 0.37 log MAR at 1 month (p = 0.003).<BR><B>CONCLUSIONS: </B>Eyes treated with IDI showed significant decrease in CRT detectable 1 day after injection. In some patients, the effect could be observed 3 h post-implantation.<BR><B>BACKGROUND: </B>Clinicaltrials.gov NCT05736081 . Registered 20 February 2023, Retrospectively registered.