%0 Journal Article
%T Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn.
%A Gradwell MA
%A Ozeri-Engelhard N
%A Eisdorfer JT
%A Laflamme OD
%A Gonzalez M
%A Upadhyay A
%A Medlock L
%A Shrier T
%A Patel KR
%A Aoki A
%A Gandhi M
%A Abbas-Zadeh G
%A Oputa O
%A Thackray JK
%A Ricci M
%A George A
%A Yusuf N
%A Keating J
%A Imtiaz Z
%A Alomary SA
%A Bohic M
%A Haas M
%A Hernandez Y
%A Prescott SA
%A Akay T
%A Abraira VE
%J Neuron
%V 112
%N 8
%D 2024 Apr 17
%M 38452762
%F 18.688
%R 10.1016/j.neuron.2024.01.027
%X Sensory feedback is integral for contextually appropriate motor output, yet the neural circuits responsible remain elusive. Here, we pinpoint the medial deep dorsal horn of the mouse spinal cord as a convergence point for proprioceptive and cutaneous input. Within this region, we identify a population of tonically active glycinergic inhibitory neurons expressing parvalbumin. Using anatomy and electrophysiology, we demonstrate that deep dorsal horn parvalbumin-expressing interneuron (dPV) activity is shaped by convergent proprioceptive, cutaneous, and descending input. Selectively targeting spinal dPVs, we reveal their widespread ipsilateral inhibition onto pre-motor and motor networks and demonstrate their role in gating sensory-evoked muscle activity using electromyography (EMG) recordings. dPV ablation altered limb kinematics and step-cycle timing during treadmill locomotion and reduced the transitions between sub-movements during spontaneous behavior. These findings reveal a circuit basis by which sensory convergence onto dorsal horn inhibitory neurons modulates motor output to facilitate smooth movement and context-appropriate transitions.