%0 Journal Article
%T Evaluation of HLA-DQ2 and HLA-DQ8 haplotypes in patients with endometriosis, A case-control study.
%A Andres MP
%A Peloggia A
%A Abrao HM
%A Magalhaes TF
%A Neto JS
%A Abrão MS
%J Clinics (Sao Paulo)
%V 79
%N 0
%D 2024 Mar 2
%M 38432123
%F 2.898
%R 10.1016/j.clinsp.2023.100317
%X To evaluate the relationship between genetic haplotypes associated with celiac disease (Human Leucocyte Antigen [HLA] DQ2 and DQ8) with the diagnosis, clinical presentation, and location of endometriosis in Brazilian women.<BR>A retrospective cross-sectional study, was conducted in a Tertiary hospital.<BR>Women aged 18-50 years who underwent HLA-DQ2 and HLA-DQ8 haplotype analysis.<BR>The patients were divided into endometriosis and control groups and evaluated for symptoms; endometriosis location, American Society for Reproductive Medicine (ASRM) stage, and the presence of anti-tissue transglutaminase IgA (anti-TgA), HLA-DQ2, and HLA-DQ8 markers.<BR>A total of 434 consecutive patients with (n = 315) and without (n = 119) endometriosis were included. Pain and infertility were more frequent in the endometriosis group than in the control group. The presence of HLA-DQ2, HLA-DQ8, and anti-TgA was similar between both groups. The presence of HLA-DQ2 and HLA-DQ8 markers did not differ based on age, pain symptoms, ASRM stage, or endometriosis location.<BR>Although there are similarities in inflammatory markers and pathophysiology between celiac disease and endometriosis, this study found no significant associations in the presence of HLA-DQ2 or HLA-DQ8 haplotypes and endometriosis.