%0 Systematic Review
%T Early Organ Metastasis in Granulomatous Mycosis Fungoides: A Systematic Review.
%A Motamedi M
%A Xiao MZX
%A Deschenes J
%A Hardin J
%A Sterrett R
%A Street L
%A Taparia M
%A Mahe E
%A Ferrara G
%A Barrie JR
%A Gniadecki R
%J Dermatology
%V 240
%N 3
%D 2024 Feb 29
%M 38422999
%F 5.197
%R 10.1159/000537893
%X <B>BACKGROUND: </B>Granulomatous mycosis fungoides (GMF) is a rare form of cutaneous T-cell lymphoma characterized by a granulomatous inflammatory infiltrate.<BR><B>OBJECTIVE: </B>The impact of granulomatous inflammation on the prognosis of the disease remains controversial as there have been both favorable and unfavorable outcomes documented.<BR><B>METHODS: </B>We performed a systematic review of 116 GMF cases previously described in the literature.<BR><B>RESULTS: </B>In contrast to the classic Alibert-Bazin type of mycosis fungoides (MF), cutaneous lesions in GMF tend to involve distal extremities (lower legs, feet, hands) early in the disease course. In the literature, 30% of GMF patients developed organ metastasis, most frequently to the lung. The median time to stage progression was 25 months.<BR><B>CONCLUSIONS: </B>GMF is an aggressive form of MF. Therefore, screening for distant metastases should be considered at presentation and repeated during follow-up.