%0 Journal Article
%T Cangrelor in contemporary patients with ST-segment elevation myocardial infarction pretreated with Ticagrelor: Pharmacodynamic data from the POMPEII study.
%A Gargiulo G
%A Cirillo P
%A Sperandeo L
%A Forzano I
%A Castiello DS
%A Florimonte D
%A Simonetti F
%A Paolillo R
%A Manzi L
%A Spinelli A
%A Spaccarotella CAM
%A Piccolo R
%A Di Serafino L
%A Franzone A
%A Capranzano P
%A Valgimigli M
%A Esposito G
%J Int J Cardiol Heart Vasc
%V 50
%N 0
%D 2024 Feb
%M 38419600
暂无%R 10.1016/j.ijcha.2024.101344
%X UNASSIGNED: There are limited data to assess pharmacodynamic (PD) profiles of patients with STEMI undergoing primary percutaneous coronary intervention (PCI) and receiving cangrelor after pretreatment with ticagrelor.
UNASSIGNED: The PharmacOdynaMic effects of cangrelor in PatiEnts wIth acute or chronIc coronary syndrome undergoing percutaneous coronary intervention (POMPEII) registry (NCT04790032) is a prospective study conducted at Federico II University of Naples enrolling all patients undergoing PCI receiving cangrelor at operator's discretion. PD assessments were performed with 3 assays: (1) the gold standard light transmittance aggregometry (LTA) (20- and 5-μM adenosine diphosphate [ADP] stimuli); (2) VerifyNow P2Y12-test; (3) Multiplate electrode aggregometry (MEA), ADP-test.
UNASSIGNED: We analyzed 13 STEMI patients pretreated with ticagrelor within 1 h at the time they underwent primary PCI receiving cangrelor. All patients showed low maximal platelet aggregation at 30-minute during cangrelor infusion, as well as at 3 h and 4-6 h (corresponding to 1 h and 2-4 h after stopping cangrelor infusion) with no cases of high residual platelet reactivity. These results were consistent with all assays.
UNASSIGNED: PD data show that in contemporary real-world STEMI patients pretreated within 1 h with ticagrelor undergoing primary PCI, adding cangrelor resulted in fast and potent platelet inhibition, thus suggesting that cangrelor may bridge the gap until ticagrelor reaches its effect.