%0 Journal Article
%T Membranes are functionalized by a proteolipid code.
%A Kervin TA
%A Overduin M
%J BMC Biol
%V 22
%N 1
%D 2024 Feb 27
%M 38414038
%F 7.364
%R 10.1186/s12915-024-01849-6
%X Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones. The assembly of zones such as receptor clusters, protein-coated pits, lamellipodia, cell junctions, and membrane fusion sites is explained to occur through a protein-lipid code. This challenges the theory that lipids sort proteins after forming stable membrane subregions independently of proteins.