%0 Case Reports
%T Report of IRF2BP1 as a novel partner of RARA in variant acute promyelocytic leukemia.
%A Jiang M
%A Wang X
%A Yu M
%A Jiang S
%A Hong M
%A Zhou Y
%A Li F
%A Liu H
%A Zhang Z
%J Am J Hematol
%V 99
%N 5
%D 2024 May 27
%M 38410879
%F 13.265
%R 10.1002/ajh.27272
%X IRF2BP1 breaked in the middle of exon 1 at the c.322 position and fused with RARA intron 2 which is located at 3717 bp upstream of its exon 3. The fusion produced a new intron by forming a paired splicing donor GT at 9 bp downstream of RARA breakpoint and acceptor AG at the 5' end of RARA exon 3. The IRF2BP1::RARA fusion gene leads a fusion transcript involving IRF2BP1 exon 1 and RARA exon 3, linked by a 9-bp fragment derived from RARA intron 2. The patient with IRF2BP1::RARA has same clinical features of APL.