%0 Journal Article %T Future of Time-in-Range Goals in the Era of Advanced Hybrid Closed-Loop Automated Insulin Delivery Systems. %A Akturk HK %A Battelino T %A Castañeda J %A Arrieta A %A van den Heuvel T %A Cohen O %J Diabetes Technol Ther %V 26 %N 0 %D 2024 Mar %M 38377325 %F 7.337 %R 10.1089/dia.2023.0432 %X The concept of maintaining blood glucose levels within the 70-180 mg/dL range, known as time-in-range, has raised questions regarding its representation of true physiological euglycemia. Some have speculated that focusing on the time spent within the 70-140 mg/dL range, introduced as time in tight range (TITR) through the International Consensus statement, could serve as a more precise metric for assessing normoglycemia in individuals with type 1 diabetes. This article delves into the current status of TITR as an emerging marker and explores how advanced hybrid closed-loop systems may offer a promising avenue for achieving this higher level of glycemic control.