%0 Journal Article
%T Causal Effects of Lipids-Related Metabolites on Androgenic Alopecia: A Mendelian Randomization Study.
%A Bi L
%A Wang C
%A Du Y
%A Lu C
%A Zhao M
%A Ding Y
%A Sun W
%A Fan W
%J Clin Cosmet Investig Dermatol
%V 17
%N 0
%D 2024
%M 38371329
%F 2.765
%R 10.2147/CCID.S445453
%X <B>UNASSIGNED: </B>To investigate whether increased levels of lipids-related metabolites (LRMs) result in androgenic alopecia (AGA).<BR><B>UNASSIGNED: </B>A two-sample Mendelian randomization (MR) study was designed, and single nucleotide polymorphisms (SNPs) respectively related to nine LRMs were selected from the genome-wide association study (GWAS) dataset. An MR analysis was performed to assess the causal association between LRMs and AGA.<BR><B>UNASSIGNED: </B>Through the fixed-effect inverse variance weighting (IVW) method, MR analysis indicated that Apolipoprotein B (ApoB), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) had a causal relationship with AGA. No obvious heterogeneity or pleiotropy was observed.<BR><B>UNASSIGNED: </B>The risk of AGA increases significantly when the serum levels of ApoB, LDL, and VLDL increase. This causal relationship is solid and free of interference from confounding factors.