%0 Journal Article
%T Long-term outcomes and predictors of mortality in patients with pulmonary embolism undergoing catheter-directed thrombolysis: a 10-year retrospective study.
%A Gupta S
%A Cammarata TM
%A Cheah D
%A Haug N
%A Farooq TB
%A Paul V
%A Thameem D
%J Curr Probl Cardiol
%V 49
%N 5
%D 2024 May 16
%M 38369204
%F 16.464
%R 10.1016/j.cpcardiol.2024.102471
%X <B>BACKGROUND: </B>Data regarding long-term outcomes of catheter-directed thrombolysis (CDT) post intermediate risk pulmonary embolism (PE), the choice of anticoagulation, and factors affecting mortality are not well studied.<BR><B>METHODS: </B>We conducted a ten-year retrospective observational chart review of patients undergoing CDT for intermediate-risk PE. Patients were followed for a period of 1 to a maximum of 5 years from the PE event. Multivariate regression analysis was used to identify independent predictors of mortality post-CDT.<BR><B>RESULTS: </B>We had a total of 373 patients in our study. Significant 5-year mortality was observed (18.7 %) in our patient population, with a 9.2 % cardiopulmonary cause of death. Rate was highest in patients without anticoagulation (78.5 %) and least in patients on apixaban [10.9 %, absolute risk reduction - 63.8 % (40.91 % - 86.60 %)]. Age, female sex and no anticoagulation were independently associated with mortality.<BR><B>CONCLUSIONS: </B>CDT for intermediate-risk PE has a high 5-year mortality with no anticoagulation as the only modifiable risk factor.