%0 Journal Article
%T Pan-cancer proteogenomics characterization of tumor immunity.
%A Petralia F
%A Ma W
%A Yaron TM
%A Caruso FP
%A Tignor N
%A Wang JM
%A Charytonowicz D
%A Johnson JL
%A Huntsman EM
%A Marino GB
%A Calinawan A
%A Evangelista JE
%A Selvan ME
%A Chowdhury S
%A Rykunov D
%A Krek A
%A Song X
%A Turhan B
%A Christianson KE
%A Lewis DA
%A Deng EZ
%A Clarke DJB
%A Whiteaker JR
%A Kennedy JJ
%A Zhao L
%A Segura RL
%A Batra H
%A Raso MG
%A Parra ER
%A Soundararajan R
%A Tang X
%A Li Y
%A Yi X
%A Satpathy S
%A Wang Y
%A Wiznerowicz M
%A González-Robles TJ
%A Iavarone A
%A Gosline SJC
%A Reva B
%A Robles AI
%A Nesvizhskii AI
%A Mani DR
%A Gillette MA
%A Klein RJ
%A Cieslik M
%A Zhang B
%A Paulovich AG
%A Sebra R
%A Gümüş ZH
%A Hostetter G
%A Fenyö D
%A Omenn GS
%A Cantley LC
%A Ma'ayan A
%A Lazar AJ
%A Ceccarelli M
%A Wang P
%A  
%J Cell
%V 187
%N 5
%D 2024 Feb 29
%M 38359819
%F 66.85
%R 10.1016/j.cell.2024.01.027
%X Despite the successes of immunotherapy in cancer treatment over recent decades, less than <10%-20% cancer cases have demonstrated durable responses from immune checkpoint blockade. To enhance the efficacy of immunotherapies, combination therapies suppressing multiple immune evasion mechanisms are increasingly contemplated. To better understand immune cell surveillance and diverse immune evasion responses in tumor tissues, we comprehensively characterized the immune landscape of more than 1,000 tumors across ten different cancers using CPTAC pan-cancer proteogenomic data. We identified seven distinct immune subtypes based on integrative learning of cell type compositions and pathway activities. We then thoroughly categorized unique genomic, epigenetic, transcriptomic, and proteomic changes associated with each subtype. Further leveraging the deep phosphoproteomic data, we studied kinase activities in different immune subtypes, which revealed potential subtype-specific therapeutic targets. Insights from this work will facilitate the development of future immunotherapy strategies and enhance precision targeting with existing agents.