%0 Journal Article
%T Neonatal brain injury unravels transcriptional and signaling changes underlying the reactivation of cortical progenitors.
%A Foucault L
%A Capeliez T
%A Angonin D
%A Lentini C
%A Bezin L
%A Heinrich C
%A Parras C
%A Donega V
%A Marcy G
%A Raineteau O
%J Cell Rep
%V 43
%N 2
%D 2024 Feb 27
%M 38349790
暂无%R 10.1016/j.celrep.2024.113734
%X Germinal activity persists throughout life within the ventricular-subventricular zone (V-SVZ) of the postnatal forebrain due to the presence of neural stem cells (NSCs). Accumulating evidence points to a recruitment for these cells following early brain injuries and suggests their amenability to manipulations. We used chronic hypoxia as a rodent model of early brain injury to investigate the reactivation of cortical progenitors at postnatal times. Our results reveal an increased proliferation and production of glutamatergic progenitors within the dorsal V-SVZ. Fate mapping of V-SVZ NSCs demonstrates their contribution to de novo cortical neurogenesis. Transcriptional analysis of glutamatergic progenitors shows parallel changes in methyltransferase 14 (Mettl14) and Wnt/β-catenin signaling. In agreement, manipulations through genetic and pharmacological activation of Mettl14 and the Wnt/β-catenin pathway, respectively, induce neurogenesis and promote newly-formed cell maturation. Finally, labeling of young adult NSCs demonstrates that pharmacological NSC activation has no adverse effects on the reservoir of V-SVZ NSCs and on their germinal activity.