%0 Journal Article
%T NAA10 gene expression is associated with mesenchymal transition, dedifferentiation, and progression of clear cell renal cell carcinoma.
%A Duong NX
%A Nguyen T
%A Le MK
%A Sawada N
%A Kira S
%A Kondo T
%A Inukai T
%A Mitsui T
%J Pathol Res Pract
%V 255
%N 0
%D 2024 Mar 7
%M 38340582
%F 3.309
%R 10.1016/j.prp.2024.155191
%X <B>BACKGROUND: </B>We aimed to investigate the expression and prognostic role of NAA10 in clear cell renal cell carcinoma (ccRCC).<BR><B>METHODS: </B>We performed a gene expression and survival analysis based on the human cancer genome atlas database of ccRCC patients (TCGA-KIRC).<BR><B>RESULTS: </B>The patients in the TCGA-KIRC (n = 537) were divided into two subgroups: NAA10-low and NAA10-high expression groups. NAA10-high ccRCC exhibited higher T stages (p = 0.002), a higher frequency of distant metastasis (p = 0.018), more advanced AJCC stages (p < 0.001), a lower overall survival time (p = 0.036), and a lower survival rate (p < 0.001). NAA10-high ccRCC was associated with increased activity of non-specific oncogenic pathways, including oxidative phosphorylation (p < 0.001) and cell cycle progression [G2 to M phase transition (p = 0.045) and E2F targets (p < 0.001)]. Additionally, the NAA10-high tumors showed reduced apoptosis via TRIAL pathways (p < 0.001) and increased levels of activity that promoted epithelial-mesenchymal transition (p = 0.026) or undifferentiation (p = 0.01). In ccRCC, NAA10 expression was found to be a negative prognostic factor in both non-metastatic (p < 0.001) and metastatic tumors (p = 0.032).<BR><B>CONCLUSIONS: </B>In ccRCC, NAA10 expression was shown to be a negative prognostic factor related to tumor progression rather than tumor initiation, and high NAA10 expression promoted epithelial-mesenchymal transition and undifferentiation.